Vitamin C is one of the most well-known and essential nutrients for overall health––it supports immune function, collagen production, and antioxidant protection. But not all vitamin C supplements are created equal. 

The delivery method––liposomal, buffered, or powder (ascorbic acid)–– is just as important as the ingredients themselves. The way you take it can significantly impact how well your body absorbs and utilizes it. We often get questions from patients about the differences between our vitamin C products.

What Is Liposomal Delivery?

Liposomal delivery refers to a method of encapsulating nutrients or supplements in tiny lipid (fat) particles called liposomes. These microscopic bubbles are made from phospholipids, the same type of fat molecules that make up the outer layer of our own cells. This structure helps protect the active ingredients inside, making them more stable and bioavailable.

When a liposomal supplement is ingested, the liposomes act as protective carriers. They shield the nutrients from digestive enzymes and other environmental factors that could degrade them before they can be absorbed into the bloodstream. Once they reach the digestive tract, the liposomes merge with the cells lining the gut, delivering the nutrients directly into the bloodstream for maximum efficacy.

What Does Bioavailable Mean?

Bioavailability refers to the proportion of nutrients that enters the bloodstream and is made available for the body to use. Traditional supplements often lose a large portion of their effectiveness due to digestion, but liposomal delivery ensures that a greater percentage of the active ingredients reach their target destination.

What Is a Buffered Supplement?

A buffered supplement is a dietary supplement that has been combined with buffering agents, such as minerals (calcium, magnesium, potassium, or sodium), to neutralize acidity and reduce potential irritation to the stomach. This makes buffered supplements easier on the digestive system, particularly for individuals who experience stomach discomfort from acidic compounds like vitamin C or certain amino acids.

What Is Ascorbic Acid?

Ascorbic acid is the purest and most basic form of vitamin C. It is a water-soluble vitamin that acts as a powerful antioxidant, supporting immune function, collagen synthesis, and overall cellular health. Ascorbic acid in crystal or powdered form may also improve bowel motility and provide relief for those who are more prone to constipation. Ascorbic acid is highly effective but can be acidic, which may cause stomach irritation in some individuals, especially at high doses.

Comparing Different Forms of Vitamin C

Each form of vitamin C has its own advantages depending on absorption, digestive tolerance, and intended use. Here’s how they compare:

Liposomal Vitamin C

• Best for: Maximum absorption and bioavailability.

• How it works: Encapsulated in fat-based liposomes, which protect the vitamin C and enhance absorption.

• Pros: Higher intracellular levels, better tolerated by the stomach, ideal for high-dose therapeutic use.

• Cons: More expensive than other forms.

Buffered Vitamin C

• Best for: Individuals with sensitive stomachs.

• How it works: Combined with minerals (such as calcium, magnesium, or potassium) to reduce acidity.

• Pros: Gentler on the stomach, provides additional minerals.

• Cons: Slightly lower absorption than liposomal vitamin C.

Vitamin C Crystals (Ascorbic Acid or Sodium Ascorbate)

• Best for: Cost-effective high dosing and flexible intake.

• How it works: Dissolves in liquid for easy absorption.

• Pros: Affordable, improves bowel motility, easily adjustable dosage, rapidly absorbed.

• Cons: High doses may cause stomach irritations.

Choosing the right form of vitamin C depends on your personal health needs and preferences. No matter which form you choose, ensuring a consistent intake of vitamin C is key to reaping its numerous health benefits.

Always talk to a health care provider before taking any new supplements.