Senescent cells are a fascinating piece of the aging process. Senescent cells are cells that have stopped dividing and replicating but they still remain metabolically active.
Cellular senescence is a stress response mechanism induced by shortened telomeres, DNA damage, and oncogenic mutations (tumor formation). Cells in this state sometimes initially serve a protective function by preventing damaged cells from becoming cancerous. If these cells remain in our body for a long period of time and accumulate, these chronic senescent cells can lead to age-related disease.
Senescent cells produce inflammatory molecules, known as the senescence-associated secretory phenotype (SASP), which can disrupt tissue function and promote chronic inflammation.
Eliminating senescent cells can treat and prevent age related diseases like cancer, neurodegenerative disorder, and cardiovascular disease by using one of three methods. First, the use of senolytics, a class of drugs or natural compounds designed to selectively target and eliminate senescent cells. Second, inhibit SASP and third, immunosurveillance or improve our immune response to senescent cells.
The goal is to reduce the burden of these cells in the body. This mitigates inflammation and improves tissue function. There are functional and holistic approaches to support the body’s natural mechanisms for preventing and eliminating senescent cells.
Nutrition, physical activity, and stress management will always be at the forefront of any functional approach. An anti-inflammatory diet, rich in antioxidants combats free radicals and oxidative stress, a common trigger for cellular senescence. Exercise clears the immune system and strengthens our overall cellular health. Chronic stress accelerates cellular aging. There’s also evidence that intermittent fasting can reduce our senescent cell burden. Intermittent fasting plays a role in lengthening our telomeres and preventing DNA damage, which informs the bigger picture of our cellular life.
Lastly, supplements that contain compounds with senolytic properties for example quercetin and curcumin, which have anti-inflammatory properties and promote apoptosis (cell death) are a great way to enhance this process. Our Senolytic Support supplement is a blend of fisetin, the strongest senolytic agent that has been found to have broad tissue distribution – advantageous in targeting senescent cells. This supplement also contains quercetin, curcumin, and red grape powder. This blend supports clearance of senescent cells to promote health and well-being, and is extremely important when engaging in more advanced longevity therapies.
As our understanding of senescent cells expands, so does the potential for innovative approaches to support healthy aging. If we can empower our bodies to naturally fight the effects of senescent cells, it leads the way for a longer, healthier life.
